Jolyon Palmer will leave the Renault team after Sunday's Japanese Grand Prix, with Carlos Sainz racing for the French outfit in Austin.
The British driver announced the news himself on his Instagram social media account.
"Tomorrow's Japanese GP will be my last race for Renault," wrote the 26-year-old.
"With my grid penalty I'll be starting near the back but I will be giving it my all as always. Thanks everyone for the support during the last 2 years, it means a lot!"
Renault confirmed Palmer's departure and Sainz's immediate switch to the French outfit for the US Grand Prix.
“I would like to thank Jolyon for his commitment to the team and his professionalism," said Renault boss Cyril Abiteboul in a statement.
"Since Renault’s return to Formula 1, Jolyon has been highly dedicated in an evolving environment. He has shown great personal qualities and we wish him all the best in his future career.”
Sainz's move would likely prompt Toro Rosso to bring back Dany Kvyat for the US Grand Prix to race alongside Pierr Gasly if the French driver decides to miss the Super Formula finale in Japan which clashes with the Austin race.